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Shikhar Bhattarai/Stocksy As a beta-2-adrenergic agonist, clenbuterol stimulates the heart and central nervous system, so it has the opposite effect as a beta-blocker. It has a similar. Myotoxic effects of clenbuterol in the rat heart and soleus muscle. – Abstract – Europe PMC Preprints in Europe PMC. In the heart, the clenbuterol-induced necrosis was not uniform, being more abundant in the left subendocardium and peaking 2. 4 mm from the apex. However, in this case, the intake of clenbuterol can be regarded as a significant stressor for the preexisting damaged heart. Clenbuterol has also been reported as an adulterant of heroin. [ 38 ] and Wingert et al. [ 39 ] reported on clenbuterol concentrations in the blood of persons who ingested clenbuterol-contaminated heroin. We have investigated the dose- and time-dependency of myocyte apoptosis and necrosis induced by the beta2-adrenergic receptor agonist, clenbuterol, with the aim of determining whether myocyte apoptosis and necrosis are two separate processes or a continuum of events. Abstract Clenbuterol is a potent beta-2 agonist widely misused by professional athletes and bodybuilders. Information on clenbuterol associated adverse events is present in case reports and case series, though it may not be readily available Therefore, it is recommended that people with a history of heart conditions or high blood pressure avoid taking Clenbuterol, clenbuterol heart necrosis.
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